Hubungan Jumlah Cluster of Differentiation 4 (CD4) dengan Infeksi Oportunistik Pada Pasien HIV/AIDS di Rumah Sakit Umum Daerah (RSUD) DOK II Jayapura

Authors

  • Mirna Widiyanti Balai Litbang Biomedis Papua. Jln. Kesehatan No 10 Dok II, Jayapura, Papua. Kode Pos: 99580
  • Hotma Hutapea Balai Litbang Biomedis Papua, Kementerian Kesehatan Republik Indonesia

DOI:

https://doi.org/10.31957/jbp.427

Abstract

Human Immunodeficiency Virus (HIV) is an infection that attacks and weakens the immune system. HIV infection causes a decrease in the number of Cluster Differentiation 4 (CD4) thereby increasing the progression of the disease and lead to high risk of opportunistic infections (OI). The purpose of this study was to examine the relationship between CD4 cell count with opportunistic infections in patients infected with HIV/AIDS. Analytical research methods using cross-sectional design, by taking medical records. The population in this study were 67 patients with HIV/AIDS in the VCT Clinic Dok II Hospital Jayapura 2014. Data were processed with the Chi Square test hypotheses. Based on the results of hypothesis testing of 67 patients, there were 21 people have opportunistic infections. Tuberculosis is an opportunistic infection that is most common (17.9%). Significance of the relationship seen in the low CD4 counts (< 350 cells/mm3) and found value of 0.02 (CI 95%) which indicates that there is a relationship if p<0.05. Conclusion: there is a relationship between CD4 cell count with opportunistic infections.

Key words: CD4, opportunistic infection, HIV/AIDS, hospital.

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Author Biographies

Mirna Widiyanti, Balai Litbang Biomedis Papua. Jln. Kesehatan No 10 Dok II, Jayapura, Papua. Kode Pos: 99580

Balai Litbang Biomedis Papua. Jln. Kesehatan No 10 Dok II, Jayapura, Papua. Kode Pos: 99580

Hotma Hutapea, Balai Litbang Biomedis Papua, Kementerian Kesehatan Republik Indonesia

Balai Litbang Biomedis Papua, Kementerian Kesehatan Republik Indonesia

References

Back-Brito, GN, V.N.R. El Ackhar, S.M.R. Querido, S.S.F. dos Santos, A.O.C. Jorge, and A.S.M. Reis. 2011. Staphylococcus spp, Enterobacteriaceae and Pseudo-monadaceae oral isolates from Brazilian HIV-positive patients. correlation with CD4 Cell Counts and Viral Load. J Arch Oral Biol. 56: 1041–1046.

Center for Disease Control and Prevention. (CDC). 2009a. Epidemiology of HIV infection through. Available from: http://www/cdc.gov/hiv/topics/surveillance/resources/slides/general/general.pdf. [Accessed 23 Januari 2015].

Center for Disease Control and Prevention. (CDC). 2009b. Guidelines for prevention and treatment of opportunistic infection in HIV-1 infected adults and Adolescents. Available from http://www.cdc.gov/ mmwr/preview/mmwr. html.

Direktorat Jenderal Pemberantasan Penyakit Menular dan Penyehatan Lingkungan (DP2MPL). 2013. Statistik kasus HIV/AIDS di Indonesia. Kementerian Kesehatan RI. Jakarta.

Daley, C.L. 1992. An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restrigtion fragment-length polymorphism. N. Eng;. J. Med. 326: 231–235.

Ghate, M., S. Deshpande, S. Tripathy, M. Nene, P. Gedam,and S. Godbole. 2009. Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts. Int Journal Infectious Disease. (13): 1–8.

Grant, I., N. Sacktor, and J. Mc.Arthur. 2005. HIV neurocognitive disorders. The Neurology of AIDS. 2nd Ed. Oxford University Press. pp: 357-370.

Havlir, D.V. and P.F. Barnes. 1999. Tuberculosis in patients with human immunodeficiency virus infection. N. Engl. J. Med. 340: 367–373.

Lameshow, S., D.W. Homer, J. Klar, and S.K. Lawn. 1997. Besar sampel dalam penelitian kesehatan. Gadjah Mada University Press. Yogyakarta.

Nasronudin. 2007. HIV/AIDS pendekatan biologi molekuler, klinis, dan sosial. Airlangga University Press. Surabaya.

Pohan, H.T. 2006. Infeksi dibalik ancaman HIV. Penerbit Farmacia. Jakarta.

Pongasai, P., K. Atamasirikul, and S. Sungkanuparph. 2010. The role of serum cryptococal antigen screening for the early diagnosis of Cryptococcosis in HIV–infected patients with different ranges of CD4 cell counts. J. Infect. 60: 474–477.

Schluger, N.W. and W.N. Rom. 1998. The host immune responese to tuberculosis. Am. J. Respir. Crit. Care. Med. 157: 679–691.

Selwyn, P.A. 1989. A prospective study of the risk for tuberculosis among intravenous drug users with HIV infection. N Engl J Med. 320: 545–546.

Sharma, S., G.P. Dhungana, B.M. Pokhrel, and B.P. Rijal. 2010. Opportunistic Infections in Relation to CD4 Level Among HIV Seropositive Patients from Central Nepal. Nepal Med Coll Journal; 12 (1): 1-4.

Taylor, J.M., J.L. Fahey, R. Detels, and J.V. Giorgi. 1989. CD4 Percentage, CD4 Number and CD4:CD8 Ratio in HIV Infection: Which to Choose and How to Use. Journal of Acquired Immuno Deficiency Syndrome. 2(2) 114-24.

Whalen, C. 1995. Accelerated course of HIV after tuberculosis. Am. J. Respir. Crit. Care. 151: 120–135.

Widiyanti, M., S. Sandy, dan H.A. Wibowo. 2014. Analisis subtipe HW-1 dan faktor penyebarannya pada penderita HW di RS. Yowari Kabupaten Jayapura, Papua. J. Biol Papua. 6(1): 25–30.

World Health Organization (WHO). 2009. Summary of major recommendation. [serial online] [cited 2014 Jul 02]. Available from : http://www.who.int.

Zhang, M., J. Gong, D.V. Iyer, B.E. Jones, R.L. Modlin, and P.F. Barnes. 1994. T cell cytokine respons in persons with TB and HIV infection. J. Clin Invest. 94: 2435–2442.

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Published

2018-07-28

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Research Articles