Terapi Sel Punca sebagai Inovasi dalam Pengobatan Penyakit Autoimun untuk Mempertahankan Sistem Imunitas Tubuh Manusia

Authors

  • Elysabeth Simatupang Universitas Pelita Harapan
  • Pahotkon Purba Universitas Pelita Harapan
  • Sherina Juliana Universitas Pelita Harapan
  • Yohana Ayustin Universitas Pelita Harapan
  • Wahyu Irawati Universitas Pelita Harapan

DOI:

https://doi.org/10.31957/jbp.1513

Abstract

Autoimmune is a disease caused by imbalance of immunology and losing tolerance then causes autoimmunity to attack body tissues in organisms. This disease occurs when the self-antigens attached by adaptive immune response. This disease can be treated by stem cell therapy. Stem cell therapy is an assured alternative to autoimmune treatment. Stem cells that can differentiate or can change themselves into various cells according to the environment and function to replace the damaged body cells. This study aims to find out the utility of stem cell therapy as an innovation in the treatment of autoimmune diseases. Literasture review is the method used in this research and focus to discuss: 1) the body's immune system; 2) immune system disorders; 3) autoimmune disease mechanisms; and 4) Stem cell therapy as an alternative to autoimmune treatment. Through this paper, readers will know that there is one technology to use treating autoimmune diseases, stem cell therapy. The mechanism of utilisation of stem cell therapy varies with each type of autoimmune disease, but this therapy can also cause some side effects. Stem cell therapy repairs damaged cells and replaces them with new, more functional ones. 

Key words: autoimmune disease; stem cell therapy; human body; medication.

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Author Biographies

Elysabeth Simatupang, Universitas Pelita Harapan

Pendidikan Biologi

Pahotkon Purba, Universitas Pelita Harapan

Pendidikan Biologi

Sherina Juliana, Universitas Pelita Harapan

Pendidikan Biologi

Yohana Ayustin, Universitas Pelita Harapan

Pendidikan Biologi

Wahyu Irawati, Universitas Pelita Harapan

Pendidikan Biologi

References

Antarianto, R.D., dan A.C. Barasila. 2018. Uji peduli kajian terapi sel punca untuk anak berkebutuhan khusus. Badan Penerbit Fakultas Kedokteran Universitas Indonesia. Jakarta.

Antarianto, R.D., E.J. Sitanggang, W.L. Septiana, dan C.O. Jasirwan. 2018. Potensi terapi sel punca untuk sirosis hati. Badan Penerbit Fakultas Kedokteran Universitas Indonesia. Jakarta.

Aripin, I. 2019. Pendidikan nilai pada materi konsep sistem imun. Jurnal Bio Educatio. 4(1): 1-12.

Asih, R.A., dan D.M. Sukendra. 2016. Hubungan keparahan penyakit, aktivitas, dan kualitas tidur terhadap kelelahan pasien systemic lupus erythematosus. Unnes Journal of Public Health. 5(3): 221-231.

Atkins, H.L., and M.S. Freedman. 2013. Hematopoietic stem cell therapy for multiple sclerosis: Top 10 lessons learned. Neurotherapeutics. 10(1): 68-76. DOI: 10.1007/s13311-012-0162-5

Chaplin, D. D. 2010. Overview of the immune response. Journal of Allergy and Clinical Immunology. 125(2): S3-S23. DOI: 10.1016/j.jaci.2009.12.980

Dantuma, E., S. Merchant, and K. Sugaya. 2010. Stem cells for the treatment of neurodegenerative diseases. Stem Cell Research and Therapy. 1(37): 2-7. DOI: 10.1186/scrt37.

Djauhari, T. 2010. Sel Punca. Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. 6(2): 91-96.

Dunders, G., N. Morein, dan M. Kumars. 2020. Mikrobiologi Medis II: Sterilisasi, diagnosis laboratorium, danresponsImun. Cambridge Stanford Books. Jakarta.

de Silva, N.L., and S.L. Seneviratne. 2019. Haemopoietic stem cell transplantation in systemic lupus erythematosus: A systematic review. Allergy, Asthma and Clinical Immunology. 15(59): 1-12. DOI: 10.1186/s13223-019-0373-y.

Fajriansyah, F., dan N. Najirman. 2019. Lupus Eritematosus Sistemik pada Pria. Jurnal Kesehatan Andalas. 8(3): 750-754. DOI: 10.25077/jka.v8i3.1065.

Fatimah. 2006. Respons imunitas yang rendah pada tubuh manusia usia lanjut. Makara Kesehatan 10(1): 47-53.

Fauzi, A. 2019. Rheumatid arthritis. Jurnal Kedokteran Univeristas Lampung. 3(1): 167-175.

Gao, X.H., and H.D. Chen. 2016. Practical Immunodermatologi. DOI: 10.1007/978-94-024-0902-4.

Halim, D, H. Murti, F. Sandra, A. Boediono, T. Djuwantono, dan B. Setiawan. 2010. Sistem cell: Dasar teori dan aplikasi klinis. Penerbit Erlangga. Jakarta.

Imantika, E. 2014. Peran sel punca (Stem Cells) dalam mengatasi masalah infertilitas pada wanita. Medula. 2(2): 47-55.

Jafar, Y. 2017. Tatalaksana multiple sclerosis. Continuing Medical Education. 44(3): 180-184.

Janeway, C.A. Jr., P. Travers, M. Walport, and M. J. Shlomchik. 2001. Immunobiology: The Immune System in Health and Disease. 5th edition. Garland Science. New York.

Kam, A., and R. Raveinal. 2018. Imunopatogenesis dan implikasi klinis alergi makanan pada dewasa. Jurnal Kesehatan Andalas. 7(S2): 144-151. DOI: 10.25077/jka.v7i0.842.

Kay, A., Middleton, J., and O. Kehoe. 2016. Mesenchymal stem cell therapy in rheumatoid arthritis. In P. V. Pham, Bone and Cartilage Regeneration. Springer. Ho Chi Minh City.

Khasanah, Y.C. 2015. Potensi koekspresi chimeric antigen receptor (Car) dan gen foxp3 pada sel T regulators sebagai modalitas terapi penatalaksanaan autoimun. Essence of Scientific Medical Journal. 16(2): 26-30.

Kusumo, PD. 2012. Gangguan Imunodefisiensi Primer (PID). Widya Kedokteran. Jakarta.

Levani, Y. 2018. Perkembangan sel limfosit B dan penanda untuk Flowcytometry. Jurnal Berkala Ilmiah Kedokteran dan Kesehatan. 1(5): 50-57.

Liang, J., and L. Sun. 2015. Mesenchymal stem cells transplantation for systemic lupus erythematosus. International Journal Rheumatic Disase. 18(2): 164-71.

Mackenzie, I.S., S.V. Morant, G.A. Bloomfield, T.M. MacDonald, and J. O’Riordan. 2014. Incidence and prevalence of multiple sclerosis in the UK 1990-2010: A descriptive study in the General Practice Research Database. Journal of Neurology, Neurosurgery and Psychiatry. 85(1): 76-84. DOI: 10.1136/jnnp-2013-305450.

Mak, T.W., M.E. Saunders, B.D. Jett. 2014. Primer to The Immune Response: Second Edition. DOI: 10.1016/C2009-0-62217-0.

Marmont, A.M. 2009. Treating autoimmune diseases: Is stem cell therapy the future? International Journal of Clinical Rheumatology. 4(4): 395-408. DOI: 10.2217/ijr.09.33.

Mayasari, D., dan A. Pratiwi A. 2009. Hubungan respons imun dan stres dengan tingkat kekambuhan demam tifoid pada masyarakat di wilayah puskesmas Colomadu Karanganyar. Berita Ilmu Keperawatan. 2(1): 13-18.

McCusker, C., and R. Warrington. 2011. Primary immunodeficiency. Allergy, Asthma & Clinical Immunology. 7(S1): 1-8. DOI: 10.1186/1710-1492-7-s1-s11.

Mustikaningtyas E, & Romdhoni A. 2013. Stem cell pada karsinoma nasofaring. Jurnal THT-KL. 6(1): 41-51.

Nasronudin, U. Hadi, M. Vitanata, E.A. Triyono, Bramantono, Suharto, dan I.S. Tantular. 2011. Penyakit Infeksi di Indonesia Solusi Kini & Mendatang. Pusat Penerbitan dan Percetakan. Surabaya.

Nurlaila, R., N.F. Astuti, A.D. Sulistyiwati, D.C. Cahyani, dan A. Budiyanto. 2013. Terap imunoglobin intravena pada penyakit autoimun kulit. 4(3): 133-137.

Ochi, H. 2017. Clinical features, diagnosis andtherapeutic strategies in pediatric multiple sclerosis. Clin Exp Neuroimmunol. 8(S1): 3-9.

Openshaw, H., R.A. Nash, and P.A. McSweeney. 2002. High-dose immunosuppression and hematopoietic stem cell transplantation in autoimmune disease: Clinical review. Biology of Blood and Marrow Transplantation. 8(5): 233-48. DOI: 10.1053/bbmt.2002.v8.pm12064360.

Pratiwi, A.R. 2020. Pangan untuk Sistem Imun. SCU Knowledge Media. Jawa Tengah.

Purwaningsih, E. 2013. Disfungsi telomer pada penyakit autoimun. Jurnal Kedokteran Yarsi. 21(1): 041-049.

Putra, I.B.K., R.D. Sihanto, dan I.P.E. Widyadharma. 2019. Terapi sel punca neural pada stroke iskemik. Callosum Neurology. 2(1): 25-28. DOI: 10.29342/cnj.v2i1.53.

Rahim, F., B. Arjmand, R. Tirdad, and A.S. Malehi. 2018. Stem cell therapy for multiple sclerosis. Cochrane Library. 2019(9): CD013049. DOI: 10.1002/ 14651858.CD013049.

Rifa’i, M. 2011. Autoimun dan Bioregulator. UB Press. Malang.

Rivat, C., G. Santilli, H.B. Gaspar, and A.J. Thrasher. 2012. Gene therapy for primary immunodeficiencies. Human Gene Therapy. 23(7): 668-675. DOI: 10.1089/ hum.2012.116.

Riwayanti. 2015. Reaksi hipersensitivitas atau alergi. Jurnal Keluarga Sehat Sejahtera. 13(2): 22-27. DOI: https:// doi.org/10.24114/jkss.v13i26.3593.

Rosa, S.B., J.C. Voltarelli, J.A.B. Chies, and P. Pranke. 2007. The use of stem cells for the treatment of autoimmune diseases. Brazilian Journal of Medical and Biological Research. 40(12): 1579-1597. DOI: 10.1590/S0100-879X2006005000166.

Rubenstein, D., D. Wayne, dan J. Bradley. 2007. Kedokteran Klinis (6 Ed.). Penerbit Erlangga. Jakarta.

Schultz, K.T., and F. Grieder. 1987. Structure and function of the immune system. Toxicologic Pathology. 15(3): 262-274. DOI: 10.1177/019262338701500301

Setiawan, D., R.N. Putri, dan R. Suryanita. 2019. Implementasi algoritma genetika untuk prediksi penyakit autoimun. Rabit : Jurnal Teknologi dan Sistem Informasi Univrab. 4(1): 8-19. DOI: 10.36341/ rabit.v4i1.595.

Siswanto, F.M., dan A. Pangkahila. 2014. Pelatihan fisik seimbang meningkatkan aktivitas stem cell endogen untuk anti penuaan. Jurnal Olahraga dan Fitnes. 2(1): 1-9.

Snowden, J.A., M. Badoglio, and T. Alexander. 2019. The rise of autologous HCT for autoimmune diseases: what is behind it and what does it mean for the future of treatment? An update on behalf of the EBMT Autoimmune Diseases Working Party. Expert Review of Clinical Immunology. 15(10): 981-985. DOI: 10.1080/ 1744666X.2019.1656526.

Sudiono, J. 2014. Sistem kekebalan tubuh. Penerbit Buku Kedokteran EGC. Jakarta.

Syariffudin. 2019. Imunologi Dasar: Dasar-dasar Sistem Kekebalan Tubuh. Klinik Cendekia. Indonesia.

Waluyo, S., dan Budhi. 2014. Penyakit-penyakit Autoimun. Elex Media Komputindo. Jakarta.

Weng, N ping. 2012. Telomeres and immune competency. Current Opinion in Immunology. 24(4): 1-12. DOI: 10.1016/j.coi.2012.05.001.

Wood, K.J., F. Issa, and J. Hester. 2016. Understanding stem cell immunogenicity in therapeutic applications. Trends in Immunology. 37(1): 5-16. DOI: 10.1016/ j.it.2015.11.005.

Yamamoto, K. 2004. Mechanisms of autoimmunity: Recent concept. JMAJ. 47(9): 403-406.

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Published

2022-05-16

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Research Articles