Terapi Sel Punca sebagai Inovasi dalam Pengobatan Penyakit Autoimun untuk Mempertahankan Sistem Imunitas Tubuh Manusia
https://doi.org/10.31957/jbp.1513
Abstract
Autoimmune is a disease caused by imbalance of immunology and losing tolerance then causes autoimmunity to attack body tissues in organisms. This disease occurs when the self-antigens attached by adaptive immune response. This disease can be treated by stem cell therapy. Stem cell therapy is an assured alternative to autoimmune treatment. Stem cells that can differentiate or can change themselves into various cells according to the environment and function to replace the damaged body cells. This study aims to find out the utility of stem cell therapy as an innovation in the treatment of autoimmune diseases. Literasture review is the method used in this research and focus to discuss: 1) the body's immune system; 2) immune system disorders; 3) autoimmune disease mechanisms; and 4) Stem cell therapy as an alternative to autoimmune treatment. Through this paper, readers will know that there is one technology to use treating autoimmune diseases, stem cell therapy. The mechanism of utilisation of stem cell therapy varies with each type of autoimmune disease, but this therapy can also cause some side effects. Stem cell therapy repairs damaged cells and replaces them with new, more functional ones.Â
Key words: autoimmune disease; stem cell therapy; human body; medication.
Downloads
References
Antarianto, R.D., dan A.C. Barasila. 2018. Uji peduli kajian terapi sel punca untuk anak berkebutuhan khusus. Badan Penerbit Fakultas Kedokteran Universitas Indonesia. Jakarta.
Antarianto, R.D., E.J. Sitanggang, W.L. Septiana, dan C.O. Jasirwan. 2018. Potensi terapi sel punca untuk sirosis hati. Badan Penerbit Fakultas Kedokteran Universitas Indonesia. Jakarta.
Aripin, I. 2019. Pendidikan nilai pada materi konsep sistem imun. Jurnal Bio Educatio. 4(1): 1-12.
Asih, R.A., dan D.M. Sukendra. 2016. Hubungan keparahan penyakit, aktivitas, dan kualitas tidur terhadap kelelahan pasien systemic lupus erythematosus. Unnes Journal of Public Health. 5(3): 221-231.
Atkins, H.L., and M.S. Freedman. 2013. Hematopoietic stem cell therapy for multiple sclerosis: Top 10 lessons learned. Neurotherapeutics. 10(1): 68-76. DOI: 10.1007/s13311-012-0162-5
Chaplin, D. D. 2010. Overview of the immune response. Journal of Allergy and Clinical Immunology. 125(2): S3-S23. DOI: 10.1016/j.jaci.2009.12.980
Dantuma, E., S. Merchant, and K. Sugaya. 2010. Stem cells for the treatment of neurodegenerative diseases. Stem Cell Research and Therapy. 1(37): 2-7. DOI: 10.1186/scrt37.
Djauhari, T. 2010. Sel Punca. Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. 6(2): 91-96.
Dunders, G., N. Morein, dan M. Kumars. 2020. Mikrobiologi Medis II: Sterilisasi, diagnosis laboratorium, danresponsImun. Cambridge Stanford Books. Jakarta.
de Silva, N.L., and S.L. Seneviratne. 2019. Haemopoietic stem cell transplantation in systemic lupus erythematosus: A systematic review. Allergy, Asthma and Clinical Immunology. 15(59): 1-12. DOI: 10.1186/s13223-019-0373-y.
Fajriansyah, F., dan N. Najirman. 2019. Lupus Eritematosus Sistemik pada Pria. Jurnal Kesehatan Andalas. 8(3): 750-754. DOI: 10.25077/jka.v8i3.1065.
Fatimah. 2006. Respons imunitas yang rendah pada tubuh manusia usia lanjut. Makara Kesehatan 10(1): 47-53.
Fauzi, A. 2019. Rheumatid arthritis. Jurnal Kedokteran Univeristas Lampung. 3(1): 167-175.
Gao, X.H., and H.D. Chen. 2016. Practical Immunodermatologi. DOI: 10.1007/978-94-024-0902-4.
Halim, D, H. Murti, F. Sandra, A. Boediono, T. Djuwantono, dan B. Setiawan. 2010. Sistem cell: Dasar teori dan aplikasi klinis. Penerbit Erlangga. Jakarta.
Imantika, E. 2014. Peran sel punca (Stem Cells) dalam mengatasi masalah infertilitas pada wanita. Medula. 2(2): 47-55.
Jafar, Y. 2017. Tatalaksana multiple sclerosis. Continuing Medical Education. 44(3): 180-184.
Janeway, C.A. Jr., P. Travers, M. Walport, and M. J. Shlomchik. 2001. Immunobiology: The Immune System in Health and Disease. 5th edition. Garland Science. New York.
Kam, A., and R. Raveinal. 2018. Imunopatogenesis dan implikasi klinis alergi makanan pada dewasa. Jurnal Kesehatan Andalas. 7(S2): 144-151. DOI: 10.25077/jka.v7i0.842.
Kay, A., Middleton, J., and O. Kehoe. 2016. Mesenchymal stem cell therapy in rheumatoid arthritis. In P. V. Pham, Bone and Cartilage Regeneration. Springer. Ho Chi Minh City.
Khasanah, Y.C. 2015. Potensi koekspresi chimeric antigen receptor (Car) dan gen foxp3 pada sel T regulators sebagai modalitas terapi penatalaksanaan autoimun. Essence of Scientific Medical Journal. 16(2): 26-30.
Kusumo, PD. 2012. Gangguan Imunodefisiensi Primer (PID). Widya Kedokteran. Jakarta.
Levani, Y. 2018. Perkembangan sel limfosit B dan penanda untuk Flowcytometry. Jurnal Berkala Ilmiah Kedokteran dan Kesehatan. 1(5): 50-57.
Liang, J., and L. Sun. 2015. Mesenchymal stem cells transplantation for systemic lupus erythematosus. International Journal Rheumatic Disase. 18(2): 164-71.
Mackenzie, I.S., S.V. Morant, G.A. Bloomfield, T.M. MacDonald, and J. O’Riordan. 2014. Incidence and prevalence of multiple sclerosis in the UK 1990-2010: A descriptive study in the General Practice Research Database. Journal of Neurology, Neurosurgery and Psychiatry. 85(1): 76-84. DOI: 10.1136/jnnp-2013-305450.
Mak, T.W., M.E. Saunders, B.D. Jett. 2014. Primer to The Immune Response: Second Edition. DOI: 10.1016/C2009-0-62217-0.
Marmont, A.M. 2009. Treating autoimmune diseases: Is stem cell therapy the future? International Journal of Clinical Rheumatology. 4(4): 395-408. DOI: 10.2217/ijr.09.33.
Mayasari, D., dan A. Pratiwi A. 2009. Hubungan respons imun dan stres dengan tingkat kekambuhan demam tifoid pada masyarakat di wilayah puskesmas Colomadu Karanganyar. Berita Ilmu Keperawatan. 2(1): 13-18.
McCusker, C., and R. Warrington. 2011. Primary immunodeficiency. Allergy, Asthma & Clinical Immunology. 7(S1): 1-8. DOI: 10.1186/1710-1492-7-s1-s11.
Mustikaningtyas E, & Romdhoni A. 2013. Stem cell pada karsinoma nasofaring. Jurnal THT-KL. 6(1): 41-51.
Nasronudin, U. Hadi, M. Vitanata, E.A. Triyono, Bramantono, Suharto, dan I.S. Tantular. 2011. Penyakit Infeksi di Indonesia Solusi Kini & Mendatang. Pusat Penerbitan dan Percetakan. Surabaya.
Nurlaila, R., N.F. Astuti, A.D. Sulistyiwati, D.C. Cahyani, dan A. Budiyanto. 2013. Terap imunoglobin intravena pada penyakit autoimun kulit. 4(3): 133-137.
Ochi, H. 2017. Clinical features, diagnosis andtherapeutic strategies in pediatric multiple sclerosis. Clin Exp Neuroimmunol. 8(S1): 3-9.
Openshaw, H., R.A. Nash, and P.A. McSweeney. 2002. High-dose immunosuppression and hematopoietic stem cell transplantation in autoimmune disease: Clinical review. Biology of Blood and Marrow Transplantation. 8(5): 233-48. DOI: 10.1053/bbmt.2002.v8.pm12064360.
Pratiwi, A.R. 2020. Pangan untuk Sistem Imun. SCU Knowledge Media. Jawa Tengah.
Purwaningsih, E. 2013. Disfungsi telomer pada penyakit autoimun. Jurnal Kedokteran Yarsi. 21(1): 041-049.
Putra, I.B.K., R.D. Sihanto, dan I.P.E. Widyadharma. 2019. Terapi sel punca neural pada stroke iskemik. Callosum Neurology. 2(1): 25-28. DOI: 10.29342/cnj.v2i1.53.
Rahim, F., B. Arjmand, R. Tirdad, and A.S. Malehi. 2018. Stem cell therapy for multiple sclerosis. Cochrane Library. 2019(9): CD013049. DOI: 10.1002/ 14651858.CD013049.
Rifa’i, M. 2011. Autoimun dan Bioregulator. UB Press. Malang.
Rivat, C., G. Santilli, H.B. Gaspar, and A.J. Thrasher. 2012. Gene therapy for primary immunodeficiencies. Human Gene Therapy. 23(7): 668-675. DOI: 10.1089/ hum.2012.116.
Riwayanti. 2015. Reaksi hipersensitivitas atau alergi. Jurnal Keluarga Sehat Sejahtera. 13(2): 22-27. DOI: https:// doi.org/10.24114/jkss.v13i26.3593.
Rosa, S.B., J.C. Voltarelli, J.A.B. Chies, and P. Pranke. 2007. The use of stem cells for the treatment of autoimmune diseases. Brazilian Journal of Medical and Biological Research. 40(12): 1579-1597. DOI: 10.1590/S0100-879X2006005000166.
Rubenstein, D., D. Wayne, dan J. Bradley. 2007. Kedokteran Klinis (6 Ed.). Penerbit Erlangga. Jakarta.
Schultz, K.T., and F. Grieder. 1987. Structure and function of the immune system. Toxicologic Pathology. 15(3): 262-274. DOI: 10.1177/019262338701500301
Setiawan, D., R.N. Putri, dan R. Suryanita. 2019. Implementasi algoritma genetika untuk prediksi penyakit autoimun. Rabit : Jurnal Teknologi dan Sistem Informasi Univrab. 4(1): 8-19. DOI: 10.36341/ rabit.v4i1.595.
Siswanto, F.M., dan A. Pangkahila. 2014. Pelatihan fisik seimbang meningkatkan aktivitas stem cell endogen untuk anti penuaan. Jurnal Olahraga dan Fitnes. 2(1): 1-9.
Snowden, J.A., M. Badoglio, and T. Alexander. 2019. The rise of autologous HCT for autoimmune diseases: what is behind it and what does it mean for the future of treatment? An update on behalf of the EBMT Autoimmune Diseases Working Party. Expert Review of Clinical Immunology. 15(10): 981-985. DOI: 10.1080/ 1744666X.2019.1656526.
Sudiono, J. 2014. Sistem kekebalan tubuh. Penerbit Buku Kedokteran EGC. Jakarta.
Syariffudin. 2019. Imunologi Dasar: Dasar-dasar Sistem Kekebalan Tubuh. Klinik Cendekia. Indonesia.
Waluyo, S., dan Budhi. 2014. Penyakit-penyakit Autoimun. Elex Media Komputindo. Jakarta.
Weng, N ping. 2012. Telomeres and immune competency. Current Opinion in Immunology. 24(4): 1-12. DOI: 10.1016/j.coi.2012.05.001.
Wood, K.J., F. Issa, and J. Hester. 2016. Understanding stem cell immunogenicity in therapeutic applications. Trends in Immunology. 37(1): 5-16. DOI: 10.1016/ j.it.2015.11.005.
Yamamoto, K. 2004. Mechanisms of autoimmunity: Recent concept. JMAJ. 47(9): 403-406.
Downloads
Published
Issue
Section
License
1. Copyright Policy
Jurnal Biologi Papua is committed to promoting the dissemination, accessibility, and responsible reuse of scholarly research in biology and related disciplines.
Under this policy, authors retain copyright ownership of their published articles and grant Jurnal Biologi Papua the non-exclusive right of first publication.
Authors retain the right to use, distribute, reproduce, and share their scholarly work in accordance with the applicable publication license.
The journal acknowledges the intellectual contributions of authors and respects their moral rights, including the right to be properly identified as creators of their work.
2. Publication License
Articles published under this policy are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
License URL: https://creativecommons.org/licenses/by/4.0/
Under this license, users are permitted to:
-
Share: Copy and redistribute published articles in any medium or format.
-
Adapt: Remix, transform, and build upon published materials for any purpose, including commercial purposes.
-
Redistribute: Make articles available through repositories, websites, databases, and other scholarly platforms.
These permissions are subject to the Creative Commons Attribution 4.0 International License.
Users must provide appropriate credit to the original authors, include a link to the license, and indicate whether changes have been made.
Reuse must not imply endorsement by the authors or publisher.
3. Rights of Authors
Authors publishing in Jurnal Biologi Papua retain the following rights:
-
Copyright ownership of their original scholarly work.
-
The right to distribute and share their published articles.
-
The right to deposit their articles in institutional or subject repositories.
-
The right to reuse their work in subsequent scholarly publications, subject to appropriate acknowledgment and applicable ethical standards.
-
The right to share their work for teaching, research, academic collaboration, and other lawful purposes.
Authors must acknowledge the original publication in Jurnal Biologi Papua when distributing or reusing the published version.
4. Rights of the Publisher
Authors grant Jurnal Biologi Papua the non-exclusive right to publish, disseminate, archive, and preserve accepted manuscripts.
The journal may reproduce and distribute the published version through its official website and authorized indexing, archiving, and scholarly dissemination services.
The publisher is responsible for maintaining the integrity of published content and accurately displaying copyright and licensing information.
5. Open Access Policy
Jurnal Biologi Papua supports immediate open access to scholarly research.
Articles published under this policy are freely accessible to readers without subscription requirements or access fees.
The journal encourages the responsible dissemination and reuse of published research to support scientific progress, academic collaboration, and the broader exchange of knowledge.
Published content may be accessed, downloaded, shared, and reused in accordance with the applicable Creative Commons license.
6. Third-Party Materials
Authors are responsible for ensuring that all materials included in their manuscripts comply with applicable copyright and intellectual property laws.
Permission must be obtained when required for the use of third-party figures, photographs, tables, illustrations, or other copyrighted materials.
Materials excluded from the article's Creative Commons license must be clearly identified with their applicable copyright and permission notices.
The journal's publication license does not override the rights of third-party copyright holders.
7. Repository and Self-Archiving Policy
Authors are permitted and encouraged to deposit and share their published articles through institutional repositories, academic repositories, and personal or institutional websites.
Authors must provide appropriate acknowledgment of the article's original publication in Jurnal Biologi Papua, including its citation information and DOI where available.
Repository deposits and subsequent distribution must comply with the license applicable to the relevant version of the article.
8. Licensing Information and Article Metadata
The applicable copyright holder and publication license should be clearly identified on each published article's webpage.
Where supported, licensing information should also be included in article metadata and the published PDF.
The journal is committed to maintaining accurate and consistent licensing information across its online publishing platform and scholarly indexing services.
9. Policy Application and Previously Published Articles
This policy applies to manuscripts accepted following its formal adoption by the journal and publisher.
Articles published before the adoption of this policy remain subject to the copyright arrangements and licenses applicable at the time of their publication, unless a valid change is authorized by the relevant rights holders.
The journal will not apply a new license retroactively without the necessary authorization.
10. Policy Commitment
Jurnal Biologi Papua is committed to transparent copyright arrangements, responsible open access publishing, and respect for intellectual property rights.
The journal will periodically review its copyright and licensing practices to maintain consistency with recognized standards of scholarly communication.
References
Creative Commons Attribution 4.0 International License: https://creativecommons.org/licenses/by/4.0/
Directory of Open Access Journals (DOAJ): https://doaj.org/apply/copyright-and-licensing/








