Pengaruh Pemberian Etanol Peroral terhadap Berat Testis Tikus Putih (Rattus norvegicus Strain Wistar)
DOI:
https://doi.org/10.31957/jbp.555Abstract
Alcohol (ethanol) has long been used as liquor. In some areas in Indonesia, the use of ethanol is an insaperable part of family rites and traditional festivities.  However, due to its serious consequences, alcoholism becomes a chronic social problem. Ethanol effects the metabolism in body organs and tissues, including male reproductive organ. The objective of this study was to prove that ethanol comsumption may reduce the weight of testis. This study used Posttest Only Group Design with experimental animals of 30 male rats (Wistar strain Rattus norvegicus) that were subjected in five types of treatment, i.e,(1) feeding with aquades 2ml/day as control group (2) feeding with 10% 1 gr/Kg/day of ethanol, (3) feeding with 10% 3gr/Kg/day of ethanol, (4) feeding with 30% 1 gr/Kg/day of ethanol and (5) feeding with 30% 3 gr/Kg/day of ethanol. Treatment was given daily for 45 days. At the end of the study, on the day 46th, the rats was sacrified for examination. Sample of testis were taken for weight examination.  Data were analysed using Anova and when the difference was found, the analysis was followed with Least significant Difference at the level of significance of 95%. The result of this study showed that ethanol reduced the weight of testis compared to control. The results of Anova  test revealed that higher dosage and concentrations of ethanol resulted in significantly different decrease of the testis’s weight (p<0,05) compared to other dosage and other concetration. In conclusion, ethanol has effect in the reduction of the weight of the testis.
Key words: ethanol, male reproduction, Rattus norvegicus, weight of testis.
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References
Bloom dan Fawcett. 2002. Buku Ajar Histologi. Edisi ke-12. Alih bahasa oleh J. Tambayong. Penerbit Buku EGC. Jakarta. 687-730.
Ellingboe, J. dan C.C. Varnelli. 1979. Ethanol inhibits tetosterone biosynthesis by direct action on Leydig cells. Res Commun Chem Pathol Pharmacol. 24(1): 87-102.
Emanuele MA dan N.V. Emanuele. 1998. Alcohol`s effects on male reproduction. Alcohol Health and Research World. 22(3): 195-201.
Emanuele MA dan N.V. Emanuele 2001. Alcohol and the male reproductive system. Alcohol Research and Health. Vol 25(4): 282-288.
Ganiswarna, S.G. 1995. Farmakologi dan Terapi. Edisi ke-4. Fakultas Kedokteran Universitas Indonesia. Jakarta. 143-147.
Lee, N.M., dan C.E. Becker. 1995. The Alcohols. In (Katzung BG, eds). Basic Clinical Pharmacology. 6ed. USA: Prentice Hall International Inc. 350-359.
Lu, F.C. 1995. Toksikologi Dasar. Edisi ke-2. Alih bahasa oleh E. Nugroho. Penerbit UI-Press., Jakarta. 287-95.
Paz, G.F., H. Yavetz, R. Hauser, L. Yogev, L.M. Lewin, Z.T. Homonnai. 1993. Pathophysiology of the Human Testis. In: (Insler V dan Lunenfeld Back, eds). Infertility: Male and Female. 2nd ed. Churchill Livingstone. 195-225.
Pinger, R.R., W.A. Payne, D.B. Hahn and E.J. Hahn. 1998. Drugs Issues for Today. 3rd ed. USA: WCB. McGraw-Hill: 255-269.
Pohl C.R., R.A. Guilinger and D.H. Van Thiel. 1987. Inhibitory Action of Ethnol on Luteinizing Hormone Secretion by Rat Anterior Pituitary Cells in Culture. Endocrinology 120(3): 849-852.
Tjay, T.H. dan K. Rahardja. 2002. Obat obat Penting. Edisi ke 5. Jakarta. Elex Media Computindo. 335-356.
Vander, A., J. Sherman, and D. Luciano. 2001. Human Physiology, The Mechanism of Body Function. McGraw-Hill Book Company. New York. 639-649.
Weinbauer, G.F. and E. Nieschlag. 1993. Hormonal Control of Spermatogenesis In: (Kretser D, eds) Molecular Biology of the Male Reproductive System. Academic Press Inc . USA. 99-142.
