Uji Perbandingan Penetapan Kadar Sediaan Tablet Allopurinol 300 mg Generik dengan Nama Dagang Beredar di Distrik Sentani, Jayapura
DOI:
https://doi.org/10.31957/jbp.770Abstract
Allupurinol is a medicine to treat gout especially to minimize the quantity of uric acid inside human blood. This study aims to understand the quality of gout drugs particularly the standard of Allupurinol between generic 300 mg and others Allupurinol tablet in retails at Jayapura Regency. Survey method has been used and samples were collected from Sentani district, Jayapura Regency. Spectrophotometer was used to determine the rate of Allupurinol. The results proved that in Allupurinol generic (A) the rate was 100.28% and generic (B) was 99.044%. For others tablet non generic with naming (a) the rate of Allupurinol as 99.46% while (b) was 100.77%. It means the averages of Allupurinol contain in generic was 99.6% and non-generic was 100.12%. According to Indonesian Farmakope Manual 4th Edition, the rate of Allupurinol contains in a drug must be 93.0% for minimum and can’t be more than 107.0%. Our study shown that Allupurinol generic with (A) label and non-generic with (b) label are based on the Indonesian Farmakope Standard 4th Edition. Â
Key words:Â Tablet Allopurinol, Penetapan generik, Jayapura. Â
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References
Anief, M. 1986. Ilmu farmasi. Penerbit Ghalia Indonesia. Jakarta.
Anief, M. 1991. Apa yang perlu diketahui tentang obat. Penerbit Gadjah Mada University Press. Yogyakarta.
Anonim. 2012. http://itatrie.blogspot.com/2012/10/laporan-kimia-analitik-spektrofotometri.html
Ansel, H.C. 1989. Pengantar bentuk sediaan farmasi. Edisi Keempat. UI Press, Jakarta.
Ditjen POM. 1979. Farmakope Indonesia. Edisi III. Departemen Kesehatan Indonesia RI. Jakarta.
Ditjen POM. 1995. Farmakope Indonesia. Edisi IV. Departemen Kesehatan Indonesia RI. Jakarta.
Ditjen POM. 2005. Farmakope Cina. Volume II. Departemen Kesehatan Indonesia. Jakarta.
Ernawati, dan H. Susanti. 2014. Penghambatan aktivitas xanthine oxidase oleh ekktrak etanol sarang semut (Myrmecodia tuberosa (non Jack) Bl.) secara in vitro. Pharmaçiana. 4(1): 15-22.
Katzung, B.G. 2002. Farmakologi dasar dan klinik buku 3. Edisi 8. Penerjemah dan editor: Bagian Farmakologi FK UNAIR. Penerbit Salemba Medika. Jakarta.
Kusuma, A.M., R. Wahyuningrum, dan T. Widyati. 2014. Aktivitas antihiperurisemia ekstrak etanol herba pegagan pada mencit jantan dengan induksi kafein. Pharmacy. 11(1): 62-74.
Mulyono, H.B., dan T.L. Jembise. 2018. Hubungan kebiasaan minum teh terhadap kejadian gout athritis pada warga Jamaah Masjid Al Manshuurin Yabansai, Waena Jayapura. J. Biol. Papua. 10(2): 56-61.
Munaf, S. 1994. Catatan kuliah farmakologi. EGC Press. Jakarta.
Priyanto dan L. Batubara. 2008. Farmakologi dasar. Edisi II. Penerbit Leskonfi. Jakarta.
Rahmah, N.F., A. Mukaddas, dan Safarudin. 2016. Profil penggunaan obat pada pasien gout dan hiperurisemia di RSU Anutapura Palu. Galenika, Journal of Pharmacy. 2(2): 118-123.
Soekemi, A.R. 1987. Tablet. Penerbit PT. Mayang Kencana. Medan.
Syamsuni, A. 2006. Ilmu resep. Penerbit Buku Kedokteran EGC, Jakarta.
Tarigan, I.M., S. Bahri, dan A. Saragih. 2012. Aktivitas antihiperurisemia ekstrak etanol herba Suruhan (Peperomia pellucida (L.) Kunth) pada mencit jantan. Journal of Pharmaceutics and Pharmacology. 1(1): 37- 43.
Zulkifli. 2009. Obat itu racun. Penerbit Grha Pustaka. Yogyakarta.
