Evaluasi Stabilitas Sediaan Krim Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile) dengan Basis Vanishing Cream (VC)
DOI:
https://doi.org/10.31957/jbp.130Abstract
Daun afrika (Vernonia amygdalina) contains flavonoids, tannins, saponins, and terpenoids that can be used for pharmacology activity: annihilate the parasites that causing schistosomiasis, malaria leishmaniasis, antiamoeba, antitumor and antimicrobials. The purposes of this research were to screen the phytochemistry of african leaf, formulate and test the stability of vanishing cream (VC) base. The methods used were sample collection, extract preparation, formulation, and stability evaluation. The results showed that extract afrika leaves had alkaloids, flavonoids, tannins, saponins, steroids, and triterpenoids. Extract of daun afrika can be made to good VC base formula including organoleptic test, homogeneity test, pH test, spreading test, sticky test, and VC safety test by distributing questionnaires. The cream was stabil for 21 days at room temperature. Observation of physical properties good performed every week to organoleptis, pH, adhesion, and spreading power. Â
Key words:Â stability, V. amygdalina, kill parasites, Vanishing Cream
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Adiukwu, P.C., F.I.B. Kayanja, G.K. Nambatya, S. Rugera, J.O.C. Ezeonwumelu, J.K. Tanayen, B.J. Murokore, O. Twikirize, S. Twinomujuni, D. Byamugisha, and L. Imanirampa. 2013. Antipyretic and antinociceptive properties of the aqueous extract and saponin from an edible vegetable: Vernonia amygdalina leaf. African J. Food Agr. Nutrition Dev. 13(2): 1-20.
Afolabi, A.B., A.O. Oyeyemi, T.O. Obafemi, and A.O. Fadaka. 2014. In vitro antimicrobial effects of stem bark extracts of Vernonia amygdalina. J. of Advancement in Medical and Life Sciences. 1(3): 1-3.
Akah, P.A., J.A. Alemji, O.A. Salawu, T.C. Okoye, and N.V. Offiah. 2009. Effects of Vernonia amygdalina on biochemical and hematological parameters in diabetic rats. Asian Journal of Medical Sciences. 1(3): 108-113.
Akah, P., O. Njoku, A. Nwanguma, and D. Akunyuli. 2004. Effects of aqueous leaf extract of vernonia amygdalina on blood glucose and triglyceride levels of alloxan–induced diabetic rats (Rattus rattus). Animal Research International. 1(2): 90 – 94.
Ardhita, E. 2013. Keanekaragaman tumbuhan berguna di hutan lindung Gunung Slamet RPH Baturraden, BKPH Gunung Slamet Barat, KPH Banyumas Timur. Jurusan Konservasi Sumberdaya Hutan Dan Ekowisata, Fakultas Kehutanan IPB. Bogor.
Asawalam, E.F. and A. Hassanali. 2006. Constituents of the essential oil of Vernonia amygdalina as maize weevil protectants. Tropical and Subtropical Agroecosystems. l6: 95-102.
Audu, S.A., A.E. Taiwo, A.R. Ojuolape, A.S. Sani, A.R. Bukola, and I. Mohamed. 2012. A study review of documented phytochemistry of amygdalina (family Asteraceae) as the basis for pharmacologic activity of plant extract. Journal of Natural Sciences Research. 2(7): 1-9.
Atangwho, I.J., G.E. Egbung, M. Ahmad, M.F. Yam, and M.Z. Asmawi. 2013. Antioxidant versus anti-diabetic properties of leaves from V. amygdalina. growing in Malaysia. Food Chemistry. 141: 3428-34.
BPOM. 2000. Parameter standar umum ekstrak tumbuhan obat, Departemen Kesehatan RI. Direktorat Jenderal Pengawasan Obat Dan Makanan Direktorat Pengawasan Obat Tradisional. Hal.: 10-12.
Bukar, A.M., M.A. Isa, H.S. Bello, and A.S. Abdullah. 2013. Antibacterial activityof aqueous and ethanolic leaf extracts of vernonia amygdalina on selected species of gram positive and gram negative bacteria. International Journal of Environment. 2(1): 147-151.
Ciulei, J. 1984. Metodology for analysis of vegetables and drugs. Faculty of Pharmacy. Bucharest Rumania. pp: 11-26.
Dureja, H., D. Kaushik, M. Gupta, V. Kumar, V. Lather, and V. 2005. Cosmeceuticals: An emerging concept. Indian J Pharmacol. 37(3): 155-159.
Fransworth, N.R. 1966. Biological and phytochemical screening of plant. J. pharm. Sci. 55(3): 225-265.
Erasto, P., D.S. Grierson, and A.J. Afolayan. 2008. Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina. Int. J. Environ. Res. Public Health. 5(5): 342-348.
Ibrahim, G., E.M. Abdurahman, H. Ibrahim, and N.O. Ibrahim. 2010. Comparative cytomorphological studies on the studies of V. amygdalina Del. and V. kotschyama. Nigerian Journal of Botany. 23(1): 133-142.
Ijeh, I.L., and C.E.C.C. Ejike. 2011. Current perspectives on the medicinal potentials of V. amygdalina. Journal of Medicinal Plant Research. 5(7): 1051-1061.
Marliana, S.D., V. Suryanti, dan Suyono. 2005. Skrining fitokimia dan analisis kromatografi lapis tipis komponen kimia buah labu siam (Sechium edule Jacq. Swartz.) dalam ekstrak etanol. Biofarmasi. 3(1): 26-31.
Modu, S., A.E. Adeboye, A. Maisaratu, and B.M. Mubi. 2013. Studies on the administration of V. amygdalina. (Bitter leaf) and glucophage on blood glucose level of alloxan – Induced diabetic rats. International Journal of Medicinal Plant and Alternative Medicine. 1(1): 13-19.
Momoh, M.A., U. Muhamed, A.A. Agboke, E.I. Akpabio, and E.O. Uduma. 2012. Immunological effect of aqueous extract of Vernonia amygdalina and a known immune booster called immunace® and their admixtures on HIV/AIDS clients: a comparative study. Asian Pacific Journal of Tropical Biomedicine: 181-184.
Nalule, A.S., J.M. Mbaria, and J.W. Kimenju. 2013. In vitro anthelmintic potential of Vernonia amygdalina and Secamone africana on gastrointestinal nematodes. Agriculture and biology journal of north america. Vol 4(1): 54-66.
Omoregie, E.S., A. Pal, and B. Sisodia. 2011. In vitro antimalarial and cytotoxic activities of leaf extracts of Vernonia amygdalina (del.). Nigerian Journal of Basic and Applied Science. 19(1): 121- 126.
Oriakhi, K., E.I. Oikeh, O. Ezeugwu, O. Anoliefo, O. Aguebor, and E.S. Omoregie. 2014. Comparative antioxidant activities of extracts of Vernonia amygdalina and Ocimum gratissimum leaves. Journal of Agricultural Science. 6(1): 13-20.
Robinson, T. 1995. Kandungan organik tumbuhan tingkat tinggi. Penerbit ITB. Bandung.
Sharon, N., A. Syariful, dan Yuliet. 2013. Formulasi krim antioksidan ekstrak etanol bawang hutan (Eleutherine palmifolia L. Merr). Universitas Tadulako.
Tranggono, R.I.S., F. Latifah dan J. Djajadisastra. 2007. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: PT. Gramedia Pustaka Utama.
Vasiljevic, D., G. Vuleta, and M. Primorac. 2005. The characterization of the semi-solid w/o/w emulsions with low concentraions of the primary polymeric emulsifier. Int J Cosmet Sci. 27(2): 81-87.
Zenebe, M.M., B.K. Dessie, G. Getachew, and W.H. Mariam. 2015. Isolation, structural elucidation, and bioactivity studies of leaf extract of Vernonia Amygdalina. American Journal of Applied Chemistry. 3(1): 14-20.
