Sensitivitas Antibiotik Terhadap Bakteri yang Diisolasi dari Ulkus Diabetika di RSUD Abepura, Kota Jayapura

https://doi.org/10.31957/jbp.459

Authors

  • Sulistianingsih Sulistianingsih Mahasiswa Program Pascasarjana Biologi, Universitas Cenderawasih, Jayapura
  • Dirk Y.P. Runtuboi Staf Pengajar Pascasarjana Biologi, Universitas Cenderawasih, Jayapura
  • Lucky V. Waworuntu Staf Pengajar Pascasarjana Biologi, Universitas Cenderawasih, Jayapura

Abstract

Diabetic ulcer is a complication of Diabetes mellitus that is often found on the legs and easily develop into an infection. For the prevention of this symtomps, antibiotic is required to accelerate the wound healing process. The purpose of this study was to determine the bacteria that infect diabetic ulcers and antibiotic sensitivity test against the bacterial isolates in Abepura hospitals, Jayapura. This study used exploratory laboratory and was conducted at the Regional Health Laboratory (Labkesda) in Jayapura. The results of the isolation and identification showed that 6 species of bacteria have been found. The bacteria which most infected patients with diabetic ulcers in hospitals Abepura was Escherichia coli (38%). The result of antibiotic sensitivity test in hospitals Abepura ceftazidime therapy, showed that antibiotic sensitivity of Siprofloxacin therapy was only 16.7%. Imipenem choice of antibiotics had a sensitivity of 100% againts 6 types of bacteria that cause infections in patients with diabetic ulcers. Other choices of antibiotics which had a sensitivity of over 50% is Nitrofurantoin (83.3%), Gentamicin, Kanamycin and Polymyxin B and 66.7% respectively.

Key words: Bacterial infections, diabetic ulcers, antibiotic sensitivity

Downloads

Download data is not yet available.

Author Biographies

Sulistianingsih Sulistianingsih, Mahasiswa Program Pascasarjana Biologi, Universitas Cenderawasih, Jayapura

Mahasiswa Program Pascasarjana Biologi, Universitas Cenderawasih, Jayapura

Dirk Y.P. Runtuboi, Staf Pengajar Pascasarjana Biologi, Universitas Cenderawasih, Jayapura

Staf Pengajar Pascasarjana Biologi, Universitas Cenderawasih, Jayapura 

Lucky V. Waworuntu, Staf Pengajar Pascasarjana Biologi, Universitas Cenderawasih, Jayapura

Staf Pengajar Pascasarjana Biologi, Universitas Cenderawasih, Jayapura

References

Akbar., G. Tiara, J. Karimi, dan D. Anggraini, 2014. Pola bakteri resistensi antibiotik pada ulkus diabetika Grade II di RSUD Arifin Achmad. JOM. 1(2): 1–15.

Aulia, N.F. 2008. Pola kuman aerob dan sensitivitas pada ganggren diabetik Di RSUP H. Adam Malik. [Tesis]. Universitas Sumatra Utara, Medan.

Bader. M.S. 2008. Diabetic foot infection. Journal American Family Physician. 78(1): 71–79.

Citron, M.D., E.J.C.V. Goldstein, B.A. Merriam, Lipsky and A.M. Abamson. 2007. Bakteriology of moderate-to-severe diabetic foot infections and in vitro aktivity of antimikrobial agents. Journal of Clinical Microbiology. 45(9): 2819–2828.

Decroli, E., J. Karimi, A. Manaf dan S. Syahbuddin. 2008. Profil ulkus diabetik pada penderita rawat inap di bagian penyakit dalam RSUP Dr. M Djamil Padang. Majalah Kedokteran Indonesia. 58 (1): 3–7.

Fauziyah, S., B.M. Radji dan A. Nurgani. 2011. Hubungan penggunaan antibiotik terapi empiris dengan kepekaan bakteri di ICU RSUP Fatmawati, Jakarta. Jurnal Farmasi Indonesia. 5(3): 150–158.

Hastuti, T.R. 2008. Faktor-faktor risiko ulkus diabetika pada penderita diabetes mellitus. [Tesis]. Universitas Diponogoro, Semarang.

Hijriah, R. S. Winarsih., D. Lyrawati. 2013. Efek antibakteri madu apel dan madu lebah klanceng terhadap Staphylococcus aureus isolat C34P secara in vitro. Jurnal penelitian Program Studi Pendidikan Dokter Fakultas kedokteran, Universitas Brawijaya.

IDF. 2012. http://www.idf.org/sites/default/files/5E_IDF AtlasPoster_2012_EN.pdf. Diabetes Atlas: 19 September, 2013. Pkl 23:22.

Jawetz., Melnick., dan Adelberg’s. 2007. Mikrobiologi kedokteran. Alih bahasa bagian Mikrobiologi Fakultas Kedokteran Universitas Airlangga. Salemba Medika: Jakarta.

Juwita, S.E. Hartoyo, Yulia B. Lia. 2013. Pola sensitivitas in vitro Salmonella thphy terhadap antibiotik kloramfenicol, amoksisilin dan kotrimoksazol. Jurnal Berkala Kedokteran. 9(1): 21–29.

Kahuripan, A., R. Andrajati dan T. Syahfridani. 2009. Analisis pemberian antibiotik berdasarkan uji sensitivitas terhadap pencapaian clinikal outcome pasien infeksi ulkus diabetika di RSUD Dr. H Abdul Moelek Lampung. Majalah Ilmu Kefarmasian. 6(2): 75–87.

Lipsky, A.B., A.R. Berendt, B.P. Cornia., P.C. James, J.G.E. Peters, and G.D. Amstrong. 2012. Infectious diseases society of America clinical practice quideline for the diagnosis and treatment of diabetic foot infections. Clinical Infectious Diseases. 54(12): 132–173.

Lipsky, A.B., J.K. Horloyd, and M. Zasloff. 2008. Topical versus systemic antimicrobial theraphy for treating mildly infected diabetic foot ulcers: A randomized, controlled, double-blinded multicenter trial of pexiganan cream. Clinical Infectious Diseases. (47):1537-1545.

Malik, N., and V. Shinde. 2014. Antibiotic susceptibility pattrens of phatogens isolated from diabetic foot ulcers. Journal Emp Bio. 1(2): 49–57.

Manganti, A. 2012. Panduan hidup sehat bebas diabetes. Penerbit Araska. Yogyakarta.

Peral. C.M., M.M. Rachid N. Gobbato., M.M.A. Huaman and C.Z. Voldez. 2010. Interlukin-8 production by polymorphonuclear leukocytes from patients with cronic infected legs ulcers treated with Lactobacillus plantarum. Journal Compilations European Society of Clinical Microbiology and Infectious Diseases. 16(3): 281-286.

Pramana, W., Eka, M. Suryani dan M. Supriyono. 2012. Efektivitas pengobatan madu alami terhadap penyembuhan luka infeksi kaki diabetik (IKD). Jurnal Ilmu Keperawatan dan Kebidanan. 1(2).

Redel, H., Z. Gao, H. Li, V.A. Alekseyenko, Y. Zhou, I.G. Peres. G.C. Weinstock E. Sodergen and J.M. Bloser. 2013. Quntitation and composition of cutaneous mikrobiota in diabetic and non diabetic men. The Journal of Infectious Diseases. 207: 1105-1114.

Rio, P., Y. Berry, D. Azis dan Asterina. 2012. Perbandingan efek antibakteri madu asli sikabu dengan madu lubuk minturun terhadap Escherichia coli dan Staphylococcus aureus secara in vitro. Jurnal Kesehatan Andalas. 1(2): 59–62.

Riskesdas. 2007. Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan. Republik Indonesia.

Septiari, B.B. 2012. Infeksi nosokomial. Penerbit Nuha Medika. Yogyakarta.

Sugandhi, P., and A. Prasenth D. 2014. Bacteriological profile of diabetic foot infections. International Journal of Innovative Research in Sciense Enginering and Technology. 3(7): 14688–14692.

Suresh, A., G. Muthu R. Srivani and A. Moses. 2011. Aerobic bacterial resistance in diabetic foot ulcers from Chennai. International Journal of Pharma and Bio Sciences. 2(2): 517-528.

Sutjahjo, A. 2012. Kuman dan uji kepekaan antibiotik di kaki diabetik. Indonesian Journal of Clinical Pathologi and Medical Laboratory. 20(1): 20–24.

Wikansari, N., H. Retno, dan R. Budi. 2012. Pemeriksaan total kuman udara dan Staphylococcus aureus di ruang rawat inap Rumah Sakit X Kota Semarang. Jurnal Kesehatan Masyarakat. 1(2): 384–492.

Witanto, D., Y.H. Gejali, Sandy dan L.H.P. Sakti. 2009. Gambaran umum perawatan ulkus diabetikum pada pasien rawat inap di Rumah Sakit Imannuel Bandung. Jurnal Kesehatan Masyarakat. 9(1): 34-49.

Zakaria, K. 2010. Profil penggunaan obat generik berlogo dan obat generik bermerek (branred generic) anti diabetik oral di instalasi rawat inap Rumah Sakit Umum Daerah Dr. Moewardi Surakarta. [Skripsi]. Fakultas Farmasi. Universitas Muhamadiyah Surakarta.

Downloads

Published

2018-08-01

Issue

Vol. 6 No. 2 (2014)

Section

Research Articles

License

1. Copyright Policy

Jurnal Biologi Papua is committed to promoting the dissemination, accessibility, and responsible reuse of scholarly research in biology and related disciplines.

Under this policy, authors retain copyright ownership of their published articles and grant Jurnal Biologi Papua the non-exclusive right of first publication.

Authors retain the right to use, distribute, reproduce, and share their scholarly work in accordance with the applicable publication license.

The journal acknowledges the intellectual contributions of authors and respects their moral rights, including the right to be properly identified as creators of their work.

2. Publication License

Articles published under this policy are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).

License URL: https://creativecommons.org/licenses/by/4.0/

Under this license, users are permitted to:

  1. Share: Copy and redistribute published articles in any medium or format.

  2. Adapt: Remix, transform, and build upon published materials for any purpose, including commercial purposes.

  3. Redistribute: Make articles available through repositories, websites, databases, and other scholarly platforms.

These permissions are subject to the Creative Commons Attribution 4.0 International License.

Users must provide appropriate credit to the original authors, include a link to the license, and indicate whether changes have been made.

Reuse must not imply endorsement by the authors or publisher.

3. Rights of Authors

Authors publishing in Jurnal Biologi Papua retain the following rights:

  1. Copyright ownership of their original scholarly work.

  2. The right to distribute and share their published articles.

  3. The right to deposit their articles in institutional or subject repositories.

  4. The right to reuse their work in subsequent scholarly publications, subject to appropriate acknowledgment and applicable ethical standards.

  5. The right to share their work for teaching, research, academic collaboration, and other lawful purposes.

Authors must acknowledge the original publication in Jurnal Biologi Papua when distributing or reusing the published version.

4. Rights of the Publisher

Authors grant Jurnal Biologi Papua the non-exclusive right to publish, disseminate, archive, and preserve accepted manuscripts.

The journal may reproduce and distribute the published version through its official website and authorized indexing, archiving, and scholarly dissemination services.

The publisher is responsible for maintaining the integrity of published content and accurately displaying copyright and licensing information.

5. Open Access Policy

Jurnal Biologi Papua supports immediate open access to scholarly research.

Articles published under this policy are freely accessible to readers without subscription requirements or access fees.

The journal encourages the responsible dissemination and reuse of published research to support scientific progress, academic collaboration, and the broader exchange of knowledge.

Published content may be accessed, downloaded, shared, and reused in accordance with the applicable Creative Commons license.

6. Third-Party Materials

Authors are responsible for ensuring that all materials included in their manuscripts comply with applicable copyright and intellectual property laws.

Permission must be obtained when required for the use of third-party figures, photographs, tables, illustrations, or other copyrighted materials.

Materials excluded from the article's Creative Commons license must be clearly identified with their applicable copyright and permission notices.

The journal's publication license does not override the rights of third-party copyright holders.

7. Repository and Self-Archiving Policy

Authors are permitted and encouraged to deposit and share their published articles through institutional repositories, academic repositories, and personal or institutional websites.

Authors must provide appropriate acknowledgment of the article's original publication in Jurnal Biologi Papua, including its citation information and DOI where available.

Repository deposits and subsequent distribution must comply with the license applicable to the relevant version of the article.

8. Licensing Information and Article Metadata

The applicable copyright holder and publication license should be clearly identified on each published article's webpage.

Where supported, licensing information should also be included in article metadata and the published PDF.

The journal is committed to maintaining accurate and consistent licensing information across its online publishing platform and scholarly indexing services.

9. Policy Application and Previously Published Articles

This policy applies to manuscripts accepted following its formal adoption by the journal and publisher.

Articles published before the adoption of this policy remain subject to the copyright arrangements and licenses applicable at the time of their publication, unless a valid change is authorized by the relevant rights holders.

The journal will not apply a new license retroactively without the necessary authorization.

10. Policy Commitment

Jurnal Biologi Papua is committed to transparent copyright arrangements, responsible open access publishing, and respect for intellectual property rights.

The journal will periodically review its copyright and licensing practices to maintain consistency with recognized standards of scholarly communication.

References

Creative Commons Attribution 4.0 International License: https://creativecommons.org/licenses/by/4.0/

Directory of Open Access Journals (DOAJ): https://doaj.org/apply/copyright-and-licensing/