Tumbuhan Duku: Senyawa Bioaktif, Aktivitas Farmaklogis dan Prospeknya dalam Bidang Kesehatan
https://doi.org/10.31957/jbp.528
Abstract
Lansium domesticum Corr. (Meliaceae) is the popular tropical plant producing economic edible fruits found mainly in Southeast Asia. Seed, leaf, bark, stalks and fruit skin extracts of this plant are potential sources for compounds with broad spectrum of pharmacological activities such as antitumor, anticancer, antimalaria, antimelanogenesis, antibacteria and it may lead to the discovery of a new compouds used for antimutagenic and antioxidative stress. Bioactive compounds, pharmacological activities and prospect this plant in medical application will be discussed in this paper.Â
Key words: Lansium domesticum, bioactive compounds, pharmacological activities, medical application.Â
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Arnason, J.T., B.J.R. Philoge`ne, N. Donskov, M. Hudon, C. McDougall, G. Fortier, P. Morand, D. Gardner, J. Lambert, C. Morris, and C. Nozzolillo. 1985. Antifeedant and insecticidal properties of azadirachtin to the European corn borer, Ostrinia nubilalis Hubner. Entomol. Experim. et Applicata. 38: 29-34.
Arung, E.T., I.W. Kusuma, E.O. Christy, K. Shimizu, dan R. Kondo. 2009. Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis. J Nat Med. 63(4): 473-480.
Ampasavate, C., S. Okonogi. and S. Anuchapreeda. 2010. Cytotoxicity of extracts from fruit plants against leukemic cell lines. African J. Pharm. Pharmacol. 4(1): 013-021.
Brandenburg, W.A. 1986. Classification of cultivated plants. Acta Horticulturae. 182: 109-115.
Fun, H.-K., S. Chantrapromma, N. Boonnak, K. Chaiyadej, K. Chantrapromma. and X.-L. Yu. 2006. Seco-Dukunolide F: a new tetranortriterpenoid from Lansium domesticum Corr. Acta Cryst. E62: o3725-o3727.
Hanum, L., R.S. Kasiamdari, Santosa and Rugayah. 2012. Genetic relatedness among duku, kokosan, and pisitan in Indonesia based on Random Amplified Polymorphic DNA Markers. Indonesian J Biotech. 17(2): 121-131.
Hanum, L., R.S. Kasiamdari, Santosa dan Rugayah. 2013a. Karakteristik makromorfologi dan mikromorfologi duku, kokosan, langsat dalam penentuan status taksonomi pada kategori infraspesies. Jurnal Biospecies (submitted).
Hanum, L., R.S. Kasiamdari, Santosa and Rugayah. 2013b. The phylogenetic relationship of different varieties of Lansium domesticum Correa based on ITS rDNA sequences. Seminar Nasional Bioteknologi UGM “Penguatan penguasaan bioteknologi menuju kemajuan bangsaâ€. Sekolah Pasacasarjana UGM, 11 Mei 2013.
Hettercheid, W.L.A., R.G. Van Den Burg, and W.A. Brandenburg. 1996. An annotated history of the principles of cultivated plant classification. Acta Bot Neerl. 45(2): 123-134.
Isfaeni, H., H.R. Filani, and I.A. Pertiwi. 2012. Repellency of Lansium domesticum peels extract to Nilaparvata lugens (Homoptera) on Oryza sativa IR 42. Proc Soc Indon Biodiv Intl Conf. 1: 55-58.
Isman, M.B., H. Matsuura, S. MacKinnon, T. Durst, G.H.N. Towers. and J.T. Arnason. 1997. Phytochemistry of the Meliaceae. Recent Advances in Phytochemistry. 30: 155-178.
Keng, H. 1969. Order and Families of Malayan Seed Plants. University of Malaya Press., Kuala Lumpur. pp: 181-182.
Klungsupya, P., N. Suthepakul, S. Laovitthayanggoon, A.J. Thongdon, S. Trangwacharakul, and S. Phornchirasilp. 2012. Investigation on antioxidant, antimutagenic and cytotoxic properties of active fractions of Thai longkong (Lansium domesticum Corr.) fruits. J Ethnobiol Ethnophar-macol. 1(1): 1-9.
Korompis, G.E.C., V. Danes, dan O.J. Sumampouw. 2010. Uji in vitro aktivitas antibakteri dari Lansium domesticum Correa (Langsat). Chem Prog. 3(1): 13-19.
Kulip, J. 2003. An ethnobotanical survey of medicinal and other useful plants of Muruts in Sabah, Malaysia. Telopea. 10(1): 81-98.
Leatemia, J.A and M.B. Isman. 2004. Insectisidal of crude seed extract of Annona sp, Lansium domesticum and Sandoricum koetjape against lepidopteran larvae. Phytoparasitica. 32(1): 30-37.
Leaman, D.J., J.T. Arnason, R. Yusuf, H. Sangat-Roemantyo, H. Soedjito, C.K. Angerhofer and J.M. Pezzuto. 1995. Malarial remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy. J. Ethnopharmacol. 49: 1-16.
Lim, T.K. 2012. Edible Medicinal Plant. 3th Vol. Fruits. Springer. New York.
Loekitowati, H.P. dan Hermansjah. 2000. Studi pemanfaatan biji duku (Lansium domesticum) untuk obat diare secara in vitro. Jurnal Penelitian Sains. 7: 41-48.
Mayanti, T., S. Soidah, W.D. Natawigena, U. Supratman, dan R. Tjokronegoro. 2007. Antibacterial terpenoid from the bark of Lansium domesticum Corr cv. Kokossan (Meliaceae). Research artikel was presented at International Confererence On Medicine and Medicinal Plants, Surabaya, September 8th-9th, 2007.
Mayanti, T., W.D. Natawigena, U. Supratman and R.A. Tjokronegoro. 2008. Antifeedant terpenoid from the bark of Lansium domesticum Corr cv. Kokossan (Meliaceae). Research artikel was presented at International Seminar on Chemistry 2008, Bandung 30-31 October 2008.
Mayanti, T., U. Supratman, M.R. Mukhtar, K. Awang, and S.W. Ng. 2009. Kokosanolide from the seed of Lansium domesticum Corr. Acta Cryst. E65–o750.
Mayanti, T., E. Julaeha, H. Kasmara, Nurlelasari and U. Supratman. 2011. New antifeedant triterpenoids from the peel of Lansium domesticum Corr cv. Kokossan (Meliaceae). Proceedings of the 2nd International Seminar on Chemistry 2011, Jatinangor, 24-25 November 2011. pp: 343-346.
Manosroi, A., P. Jantrawut, M. Sainakham, W. Manosroi, and J. Manosroi. 2012a. Anticancer activities of the extract from Longkong (Lansium domesticum) young fruits. Pharmaceutical Biology. Early Online: 1–11. © 2012 Informa Healthcare USA, Inc. ISSN 1388-0209 print/ISSN 1744-5116 online DOI: 10.3109/1388-0209.2012.682116.
Manosroi, A., K. Kumguan, C. Chankhampan, W. Manosroi, and J. Manosroi. 2012b. Nanoscale gelatinase A (MMP-2) inhibition on human skin fibroblasts of Longkong (Lansium domesticum Correa) leaf extracts for anti-aging. J Nanosci Nanotechnol. 12(9): 7187-7197.
Mohamed, S., Z. Hassan, and N.A. Hamid. 1994. Antimicrobial activity of some tropical fruit wastes (guava, startfruit, banana, papaya, passionfruit, langsat, duku, rambutan and rambai). Pertanika J Trop Agric Sci. 17(3): 219-227.
Monzon, R.B., J.P. Alvior, L.L.C. Luczon, A.S. Morales. and R.E.S. Mutuc. 1994. Larvicidal potential of five Philippines plants against Aedes aegypti (Linnaeus) and Culex quinquefasciatus (Say). Southeast Asian Journal of Tropical Medicine and Public Health 25: 755-759.
Morton, J. 1987. Langsat. p201-204. In Julia F.M. (ed.) Fruit of Warm Climates. Miami F.L.
Naito, Y. 1995. Medicinal Herb Index in Indonesia. 2nd ed. PT. Eisei Indonesia.
Nakasone, H.Y. and R.E. Paull. 1998. Tropical Fruits. CAB Intl, Wallingford, England. pp: 445.
Nishizawa, M., H. Nishide. and Y. Hayashi. 1982. The structure of Lansioside A: A novel triterpene glycoside with amino-sugar from Lansium domesticum. Tetrahedron Letters. 23(13): 1349-1350.
Nishizawa, M., H. Nishide, S. Kosela, and Y. Hayashi. 1983. Structure of lansiosides: biologically active new triterpene glycosides from Lansium domesticum. J. Org Chem. 48: 4462-4466.
Nishizawa, M., Y. Nademoto, S. Sastrapradja, M. Shiro. and Y. Hayashi. 1985. Structure of dukonolides, bitter principles of Lansium domesticum. J Org Chem. 50: 5487-5490.
Nishizawa, M., Y. Nademoto, S. Sastrapradja, M. Shiro, and Y. Hayashi. 1988. New tetranortriterpenoid from the seeds of Lansium domesticum. Phytochem. 27: 237–239.
Nishizawa, M., M. Emura., H. Yamada., M. Shiro., Chairul, Y. Hayashi dan H. Tozuda. 1989. Isolation of a new cycloartanoid triterpenes from leaves Lansium domesticum: novel skin-tumor promotion inhibitors. Tetrahedron Letter. 30(41): 5615–18.
Omar, S., J. Zhang, S. MacKinnon, Leaman, D. Durst, T. Philogene, B.J.R. Arnason, P.E. Sanchez-Vindas, L. Poveda, P.A. Tamez, and J.M. Pezzuto. 2003. Traditio-nally-used antimalarials from the Meliaceae. Current Topics in Medicinal Chemistry. 3(2): 133-139.
Paull, R.E., T. Goo, and N.J. Chen. 1987. Growth and compositional changes during development of lanzone fruit. Hort Sci. 22: 1252-1253.
Pantastico, Er.B., D.B. Mendoza, and R.M. Abilay. 1968. Some chemical and physiological changes during storage of lanzones (Lansium domesticum Correa.). The Philippines Agriculturist. 52: 505-517.
Ragasa, C.Y., P. Labrador, and J.A. Rideout. 2006. Antimicrobial terpenoid from Lansium domesticum. Philippine Agr Sci. 89(1): 101-105.
Saewan, N., J.D. Sutherland and K. Chantrapromma. 2006. Antimalarial tetranorterpenoids from the seeds of Lansium domesticum Corr. Phytochem. 67: 2288-2293.
Simpson, M.G. 2006. Plant Systematics. Elsevier Academic Press.
Subeki, H. M. Matsuura, Yamasaki, O. Yamato, Y. Maede, K. Katakura, M. Suzuki, Trimurningsih, Chairul and T. Yoshihara. 2004. Effect of Central Kalimantan plant extract on intraerytrhrocytic Babesia gibsoni in culture. J Vet Med Sci. 66(7): 871-874.
Supratman, U., T. Mayanti, K. Awang, M.R. Mukhtar, and S.W. Ng. 2010a. 14-Hydroxy-8,14-secogammacera-7-ene-3,21-dione from the bark of Lansium domesticum Corr. Acta Cryst. E66–o1621.
Supratman, U., T. Herlina, E. Julaeha, D. Kurnia, T. Mayanti. and D. Harneti. 2010b. Biologically Active Natural Products from Indonesian Medicinal Plants.
Tanaka, T., M. Ishibashi, H. Fujimoto, E. Okuyama, T. Koyano, T. Kowithayakorn, M. Hayashi, dan K. Komiyama. 2002. New onoceranoid triterpene constituents from Lansium domesticum. J Nat Prod. 65: 1709-1711.
Tjitrosoepomo, G. 1984. Taksonomi tumbuhan obat-obatan. Cetakan 1. GMU Press. Yogyakarta.
Tjokronegoro, R., T. Mayanti, U. Supratman, M.R. Mukhtar, and S.W. Ng. 2009. 8,14-Secogammacera-7,14(27)-diene-3,21-dione-8,14-secogammacera-7,14-diene-3,21-dione (1.5/0.5) from the bark of Lansium domesticum Corr. Acta Cryst. E65–o1448.
Verheij, E.W.M. dan R.E. Coronel. 1997. Sumber Daya Hayati Asia Tenggara 2. Prosea. PT. Gramedia Pustaka Utama, Jakarta.
Yaacob, O. and N. Bamroongrugsa. 1991. Lansium domes-ticum Correa In: Verheij, E.W.M. and Coronel, R.E. (Editors). Plant Resources of South-East Asia No. 2: Edible fruits and nuts. Pudoc, Wageningen, The Netherlands. pp: 186–190.
Yapp, D.T.T and S.Y. Yap. 2003. Lansium domesticum: skin and leaf extracts of this fruit tree interrupt the lifecycle of Plasmodium falciparum, and are active towards a chloroquine-resistant strain of the parasite (T9) in vitro. J. Ethnopharmacol. 85(1): 145–150.
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